XIAP controls RIPK2 signaling by preventing its deposition in speck-like structures
نویسندگان
چکیده
منابع مشابه
Apoptosis-associated Speck-like Protein (ASC) Controls Legionella pneumophila Infection in Human Monocytes*
The ability of Legionella pneumophila to cause pneumonia is determined by its capability to evade the immune system and grow within human monocytes and their derived macrophages. Human monocytes efficiently activate caspase-1 in response to Salmonella but not to L. pneumophila. The molecular mechanism for the lack of inflammasome activation during L. pneumophila infection is unknown. Evaluation...
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All reviewers appreciate the concept of your study and acknowledge a potential interest to a wide audience. Nevertheless, they do raise a number of important concerns, and emphasize that a substantial revision of the manuscript will be required. I would like to highlight that following the suggestions of reviewer #1, the physiological relevance of your observations needs to be addressed. Furthe...
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ژورنال
عنوان ژورنال: Life Science Alliance
سال: 2019
ISSN: 2575-1077
DOI: 10.26508/lsa.201900346